It can be done Vista, although you'll probably run out of memory trying to drive a 3 axis setup with the Prop-1. I built a 2 axis using a ST100 board for the jaw motion triggered by a Prop-1 and with ALOT of help from Jon at EFX, I got the action I wanted, but used all the available memory the Prop-1 had to offer. IF you just want nod-n-turn, the Prop-1 can handle the job. I used mine to trigger an mp3, turn on the ST100, and run the nod-turn servos. All goes like clock work without any hitch.